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bile acid simpops  (DILIsym Services Inc)

 
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    DILIsym Services Inc bile acid simpops
    Predicted maximum hepatic accumulation of CDCA and LCA species and DILI responses (i.e., minimum hepatic ATP, minimum viable liver mass, maximum serum ALT) post-dose in human <t>SimPops</t> at oral doses of 200 (green triangle), 400 (blue circle), or 600 (red diamond) mg/day TGZ for 6months (A), and rat SimPops at oral doses of 5 (blue circle) or 25 (red diamond) mg/kg/day for 6months (B).
    Bile Acid Simpops, supplied by DILIsym Services Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/bile+acid+simpops/pmc04480860-147-37-28?v=DILIsym+Services+Inc
    Average 90 stars, based on 1 article reviews
    bile acid simpops - by Bioz Stars, 2026-07
    90/100 stars

    Images

    1) Product Images from "Systems Pharmacology Modeling Predicts Delayed Presentation and Species Differences in Bile Acid-Mediated Troglitazone Hepatotoxicity"

    Article Title: Systems Pharmacology Modeling Predicts Delayed Presentation and Species Differences in Bile Acid-Mediated Troglitazone Hepatotoxicity

    Journal: Clinical pharmacology and therapeutics

    doi: 10.1038/clpt.2014.158

    Predicted maximum hepatic accumulation of CDCA and LCA species and DILI responses (i.e., minimum hepatic ATP, minimum viable liver mass, maximum serum ALT) post-dose in human SimPops at oral doses of 200 (green triangle), 400 (blue circle), or 600 (red diamond) mg/day TGZ for 6months (A), and rat SimPops at oral doses of 5 (blue circle) or 25 (red diamond) mg/kg/day for 6months (B).
    Figure Legend Snippet: Predicted maximum hepatic accumulation of CDCA and LCA species and DILI responses (i.e., minimum hepatic ATP, minimum viable liver mass, maximum serum ALT) post-dose in human SimPops at oral doses of 200 (green triangle), 400 (blue circle), or 600 (red diamond) mg/day TGZ for 6months (A), and rat SimPops at oral doses of 5 (blue circle) or 25 (red diamond) mg/kg/day for 6months (B).

    Techniques Used:

    Summary of troglitazone (TGZ)-mediated hepatotoxicity in human SimPops and clinical trials.
    Figure Legend Snippet: Summary of troglitazone (TGZ)-mediated hepatotoxicity in human SimPops and clinical trials.

    Techniques Used:

    In human SimPops administered 400 (A) or 600 (B) mg/day troglitazone (TGZ) for 6months, individuals with serum ALT elevations > 3× ULN (n=10 at 400mg/day; n=17 at 600mg/day) are presented. One individual at 400mg/day and two individuals at 600mg/day lost >85% of viable liver mass and was classified as dead.
    Figure Legend Snippet: In human SimPops administered 400 (A) or 600 (B) mg/day troglitazone (TGZ) for 6months, individuals with serum ALT elevations > 3× ULN (n=10 at 400mg/day; n=17 at 600mg/day) are presented. One individual at 400mg/day and two individuals at 600mg/day lost >85% of viable liver mass and was classified as dead.

    Techniques Used:

    Inhibition constants for BSEP, MRP4, and NTCP were altered 10-fold in either direction of the values measured in isolated transport systems . Predicted maximum serum ALT concentrations in human and rat SimPops after an oral dose of 600mg/day and 5 mg/kg/day troglitazone (TGZ), respectively, for 1month are presented. Dashed lines represent 3× baseline ALT in human (90 U/L) and rat (63 U/L) SimPops.
    Figure Legend Snippet: Inhibition constants for BSEP, MRP4, and NTCP were altered 10-fold in either direction of the values measured in isolated transport systems . Predicted maximum serum ALT concentrations in human and rat SimPops after an oral dose of 600mg/day and 5 mg/kg/day troglitazone (TGZ), respectively, for 1month are presented. Dashed lines represent 3× baseline ALT in human (90 U/L) and rat (63 U/L) SimPops.

    Techniques Used: Inhibition, Isolation



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    bile acid simpops  (DILIsym Services Inc)
    90
    DILIsym Services Inc bile acid simpops
    Predicted maximum hepatic accumulation of CDCA and LCA species and DILI responses (i.e., minimum hepatic ATP, minimum viable liver mass, maximum serum ALT) post-dose in human <t>SimPops</t> at oral doses of 200 (green triangle), 400 (blue circle), or 600 (red diamond) mg/day TGZ for 6months (A), and rat SimPops at oral doses of 5 (blue circle) or 25 (red diamond) mg/kg/day for 6months (B).
    Bile Acid Simpops, supplied by DILIsym Services Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/bile+acid+simpops/pmc04480860-147-37-28?v=DILIsym+Services+Inc
    Average 90 stars, based on 1 article reviews
    bile acid simpops - by Bioz Stars, 2026-07
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    Predicted maximum hepatic accumulation of CDCA and LCA species and DILI responses (i.e., minimum hepatic ATP, minimum viable liver mass, maximum serum ALT) post-dose in human SimPops at oral doses of 200 (green triangle), 400 (blue circle), or 600 (red diamond) mg/day TGZ for 6months (A), and rat SimPops at oral doses of 5 (blue circle) or 25 (red diamond) mg/kg/day for 6months (B).

    Journal: Clinical pharmacology and therapeutics

    Article Title: Systems Pharmacology Modeling Predicts Delayed Presentation and Species Differences in Bile Acid-Mediated Troglitazone Hepatotoxicity

    doi: 10.1038/clpt.2014.158

    Figure Lengend Snippet: Predicted maximum hepatic accumulation of CDCA and LCA species and DILI responses (i.e., minimum hepatic ATP, minimum viable liver mass, maximum serum ALT) post-dose in human SimPops at oral doses of 200 (green triangle), 400 (blue circle), or 600 (red diamond) mg/day TGZ for 6months (A), and rat SimPops at oral doses of 5 (blue circle) or 25 (red diamond) mg/kg/day for 6months (B).

    Article Snippet: Human (n=331) and rat (n=191) population samples with variability in 10 (human) or 11 (rat) parameters in the BA homeostasis sub-model (Bile Acid SimPops) were constructed previously within DILIsym using the genetic algorithm in MATLAB ; these Bile Acid SimPops are system-specific, and thus the same Bile Acid SimPops are used to simulate hepatotoxic effects of different compounds.

    Techniques:

    Summary of troglitazone (TGZ)-mediated hepatotoxicity in human SimPops and clinical trials.

    Journal: Clinical pharmacology and therapeutics

    Article Title: Systems Pharmacology Modeling Predicts Delayed Presentation and Species Differences in Bile Acid-Mediated Troglitazone Hepatotoxicity

    doi: 10.1038/clpt.2014.158

    Figure Lengend Snippet: Summary of troglitazone (TGZ)-mediated hepatotoxicity in human SimPops and clinical trials.

    Article Snippet: Human (n=331) and rat (n=191) population samples with variability in 10 (human) or 11 (rat) parameters in the BA homeostasis sub-model (Bile Acid SimPops) were constructed previously within DILIsym using the genetic algorithm in MATLAB ; these Bile Acid SimPops are system-specific, and thus the same Bile Acid SimPops are used to simulate hepatotoxic effects of different compounds.

    Techniques:

    In human SimPops administered 400 (A) or 600 (B) mg/day troglitazone (TGZ) for 6months, individuals with serum ALT elevations > 3× ULN (n=10 at 400mg/day; n=17 at 600mg/day) are presented. One individual at 400mg/day and two individuals at 600mg/day lost >85% of viable liver mass and was classified as dead.

    Journal: Clinical pharmacology and therapeutics

    Article Title: Systems Pharmacology Modeling Predicts Delayed Presentation and Species Differences in Bile Acid-Mediated Troglitazone Hepatotoxicity

    doi: 10.1038/clpt.2014.158

    Figure Lengend Snippet: In human SimPops administered 400 (A) or 600 (B) mg/day troglitazone (TGZ) for 6months, individuals with serum ALT elevations > 3× ULN (n=10 at 400mg/day; n=17 at 600mg/day) are presented. One individual at 400mg/day and two individuals at 600mg/day lost >85% of viable liver mass and was classified as dead.

    Article Snippet: Human (n=331) and rat (n=191) population samples with variability in 10 (human) or 11 (rat) parameters in the BA homeostasis sub-model (Bile Acid SimPops) were constructed previously within DILIsym using the genetic algorithm in MATLAB ; these Bile Acid SimPops are system-specific, and thus the same Bile Acid SimPops are used to simulate hepatotoxic effects of different compounds.

    Techniques:

    Inhibition constants for BSEP, MRP4, and NTCP were altered 10-fold in either direction of the values measured in isolated transport systems . Predicted maximum serum ALT concentrations in human and rat SimPops after an oral dose of 600mg/day and 5 mg/kg/day troglitazone (TGZ), respectively, for 1month are presented. Dashed lines represent 3× baseline ALT in human (90 U/L) and rat (63 U/L) SimPops.

    Journal: Clinical pharmacology and therapeutics

    Article Title: Systems Pharmacology Modeling Predicts Delayed Presentation and Species Differences in Bile Acid-Mediated Troglitazone Hepatotoxicity

    doi: 10.1038/clpt.2014.158

    Figure Lengend Snippet: Inhibition constants for BSEP, MRP4, and NTCP were altered 10-fold in either direction of the values measured in isolated transport systems . Predicted maximum serum ALT concentrations in human and rat SimPops after an oral dose of 600mg/day and 5 mg/kg/day troglitazone (TGZ), respectively, for 1month are presented. Dashed lines represent 3× baseline ALT in human (90 U/L) and rat (63 U/L) SimPops.

    Article Snippet: Human (n=331) and rat (n=191) population samples with variability in 10 (human) or 11 (rat) parameters in the BA homeostasis sub-model (Bile Acid SimPops) were constructed previously within DILIsym using the genetic algorithm in MATLAB ; these Bile Acid SimPops are system-specific, and thus the same Bile Acid SimPops are used to simulate hepatotoxic effects of different compounds.

    Techniques: Inhibition, Isolation